R&D projects

Nucaps, within its business plan and activity, proposes a continuous commitment to new R&D projects; research and development projects and the technology transfer to market.

In collaboration with the most prestigious technology centers in Navarra and with food and pharmaceutical industries, Nucaps continues researching in order to improve the solutions offered by its technology for an effective and safe oral supply of bioactives and probiotics.

This project counts with the support of the Government of Navarra and the European Union.

Nanoresveratrol

Enhancing the bioavailability of resveratrol by nanoencapsulation

 

Resveratrol (3,5,4-trihydroxystilbene) is a phytoalexin present in natural food products such as grapes, wine, peanuts, and berries with GRAS (Generally Recognised as Safe) regulatory status.

In the last years, several studies have demonstrated the potential health benefits of resveratrol. Some of these benefits are antioxidizing and anti-atherosclerosis effects, chemoprotective and cardiovascular protective effects and the capacity to inhibit platelet aggregation. However, resveratrol exhibits low stability, low water solubility and it is rapidly metabolized in vivo, which contributes to a limited cell absorption upon oral administration and therefore a very low bioavailability. Therefore, the therapeutically potential of resveratrol only will be achieve if the limitations tied to its low bioavailability are overcome.

In the last years, interest in nanotechnology has grown considerably, and researchers have investigated its use in increasing the clinical efficacy of natural products, such as resveratrol. Zein nanoparticles promote a 20-fold increase of resveratrol´s bioavailability in rats. Furthermore, the efficacy of this nanoparticles was proved in a mouse model of endotoxic shock. These nanoparticles were able to diminish the endotoxic symptoms induces by the ip administration of LPS.

In the light of these reports, Nucaps, in collaboration with Idifarma, is exploring the feasibility of the oral administration in humans of resveratrol-loaded zein nanoparticles. For this purpose, zein nanoparticles are being transfer from a laboratory scale to pilot and industrial scale and the hypothesis proved in rats, that these kind of nanocarriers can increase the bioavailability of resveratrol will be tested in humans.

 

Title: NANOCAPS

Identification Number: 0011-1365-2018-000285

Implementation period: Implementation period

Partners: NUCAPS Nanotechnology, S.L., IDIFARMA desarrollos farmacéuticos S.L.

This project has been approved by the Government of Navarre in the R&D projects 2018 call and it is co-financed (50%) by the FEDER funds through the Programa Operativo 2014-2020 de Navarra.

This enterprise has received a 50% co-financed grant by the European Regional Development Fund through the Programa Operativo FEDER 2014-2020 de Navarra.

 

Nanocaps

Looking for new encapsulation materials

 

Most nutraceutical products are intended for their oral administration. However, it remains a challenge as these substances usually present low stability within the gut and poor penetration properties directly related to their physico-chemical characteristics (e.g., molecular weight, MW, hydrophilicity, ionised groups, etc.). Moreover, in some cases they also show disgusting organoleptic characteristics.

To overcome these drawbacks and, then, promote the oral absorption and increase the bioavailability of the bioactive compounds, different strategies have been proposed. Among others, the nanoencapsulation in nanocarriers is a very promising strategy as it allows efficient loading of the nutraceuticals inside the carrier thereby protecting the cargo against degradation and promoting a controlled release, masking the odour and flavour of the active product.

In this context, food proteins such as casein, soya and zein fulfil the criteria for an ideal carrier (non-toxic, biocompatible, GRAS status…) among others such as resistance against digestive enzymes, bioadhesive capacities and hydrophobicity, which makes the preparation of colloidal structures easy.

In this context, the main objective of NanoCaps, a project in collaboration with CNTA and University of Navarra, is the design and development of new types of nanoparticles based on natural source materials.

Two strategies are being apply: on the one hand, the project works on the co-encapsulation, and surface decoration of Nucaps patented particles and, on the other hand, new materials for the encapsulation of bioactive compounds are being investigated.

 

Title: NANOCAPS

Identification Number: PT032-033 NanoCaps

Implementation period: February 2018-June 2020

Partners: Centro Nacional de Tecnología y Seguridad Alimentaria (CNTA), Universidad de Navarra (UNAV) y NUCAPS NANOTECHNOLOGY S.L.

This project has been approved by the Government of Navarre in the R&D projects 2018 call and it is co-financed (50%) by the FEDER funds through the Programa Operativo 2014-2020 de Navarra.

This project has received a 50% co-financed grant by the European Regional Development Fund through the Programa Operativo FEDER 2014-2020 de Navarra.