Innovation

At NUCAPS we have been developing and producing a new type of functional ingredients for more than 5 years. Throughout all this time, and thanks to our firm commitment to innovation, we have managed to be present in more than 21 countries around the world, with 7 families of international patents and nearly 47 active R&D projects.

International
patents

Active R+D
projects

Countries
worldwide

Toxicity Studies

Acute Toxicity Study of Zein Nanoparticles. CIFA 009/2012. University of Navarra
Toxicity Study of Zein Nanoparticles. CIFA 015/2012 – University of Navarra
Acute Toxicity Study of Casein Nanoparticles. CIFA 003/2012 – University of Navarra
Toxicity Study of Casein Nanoparticles. CIFA 010/2012 – University of Navarra

Scientific publications

Zein nanoparticles for oral folic acid delivery. Peñalva R, Esparza I, González-Navarro CJ, Quincoces G, Peñuelas I, Irache JM.. J Drug Deliv Sci Technol. 2015;30:450–7.
Doi: 10.1016/j.jddst.2015.06.012
Zein-Based Nanoparticles Improve the Oral Bioavailability of Resveratrol and Its Anti-inflammatory Effects in a Mouse Model of Endotoxic. Penalva R, Esparza I, Larraneta E, González-Navarro CJ, Gamazo C, Irache JM. Shock. J Agric Food Chem. 2015;63(23):5603–11.
Doi: 10.1021/jf505694e
Casein nanoparticles as carriers for the oral delivery of folic acid. Penalva R, Esparza I, Agüeros M, Gonzalez-Navarro CJ, Gonzalez-Ferrero C, Irache JM. Food Hydrocoll. 2015;44:399–406.
Doi: 10.1016/j.foodhyd.2014.10.004
Zein nanoparticles for oral delivery of quercetin: Pharmacokinetic studies and preventive anti-inflammatory effects in a mouse model of endotoxemia Penalva R, González-Navarro CJ, Gamazo C, Esparza I, Irache JM.. Nanomedicine. 2017 Jan;13(1):103–10.
Doi: 10.1016/j.nano.2016.08.033
Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease. Moreno LCG e. I, Puerta E, Suárez-Santiago JE, Santos-Magalhães NS, Ramirez MJ, Irache JM. Int J Pharm. 2017;517(1–2):50–7.
Doi: 10.1016/j.ijpharm.2016.11.061
Optimization and evaluation of zein nanoparticles to improve the oral delivery of glibenclamide. In vivo study using C. elegans. D. Lucio, M.C. Martínez-Ohárriz, G. Jaras, P. Aranaz, C.J. González-Navarro, A. Radulescu, J.M. Irache, , Eur. J. Pharm. Biopharm. 121 (2017) 104–112.
Doi: 10.1016/j.ejpb.2017.09.018
Thermal protection of b-carotene in re-assembled casein micelles during different processing technologies applied in food industry. María-José Sáiz-Abajo, Carolina González-Ferrero, Ana Moreno-Ruiz, Ana Romo-Hualde, Carlos J. González-Navarro. 2013. Food Chemistry.
Toxicity and biodistribution of orally administered casein nanoparticles Gil AG, Irache JM, Peñuelas I, González Navarro CJ, López de Cerain A.. Food Chem Toxicol. 2017;106:477–86.
Soybean protein-based microparticles for oral delivery of probiotics with improved stability during storage and gut resistance. González-Ferrero C, Irache JM, González-Navarro CJ.. Food Chem. 2018;239:879–88.
Doi: 10.1016/j.foodchem.2017.07.022.
Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles. Peñalva R, Morales J, González-Navarro C, Larrañeta E, Quincoces G, Peñuelas I, et al.. Int J Mol Sci. 2018;19(9):2816.
Doi: 10.3390/ijms19092816.
Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer‐Membrane Vesicles Incorporated into Zein‐Based Nanoparticles. Jose Matías, Ana Brotons, Santiago Cenoz, Isidoro Pérez, Muthanna Abdulkarim, Mark Gumbleton, Juan M. Irache, Carlos Gamazo. Vaccines 2020.
Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate Inchaurraga L, Martínez-López AL, Abdulkarim M, Gumbleton M, Quincoces G, Peñuelas I, et al.. Int J Pharm X [Internet]. 2019;1(January):100006.
Doi: 10.1016/j.ijpx.2019.100006
Casein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin. Rebeca Peñalva, Irene Esparza, Jorge Morales-Gracia, Carlos J. González-Navarro, Eneko Larrañeta, Juan M. Irache. International Journal of Pharmaceutics. 2019.
Zein nanoparticles improve the oral bioavailability of resveratrol in humans. Brotons-Canto A, Gonzalez-Navarro CJ, Gurrea J, González-Ferrero C, Irache JM. Drug Deliv Sci Technol. 2020;57(January):101704.
Zein-based nanoparticles for the oral delivery of insulin. Laura Inchaurraga, Ana L. Martínez-López, Nekane Martin-Arbella, Juan M. Irache. Drug Delivery and Translational Research.
Doi: 10.1016/j.ijpx.2019.100006
Encapsulation of Probiotics in Soybean Protein-Based Microparticles Preserves Viable Cell Concentration in Foods All Along the Production and Storage Processes. C. González-Ferrero, J.M. Irache, B. Marín-Calvo , L. Ortiz-Romero, R. Virto-Resano, C. J. González-Navarro.. J Microencapsul 37 (2020) 242-253.
Doi: https://doi.org/10.1080/02652048.2020.1724203
Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats. Ana Brotons-Canto; Carlos J. González-Navarro; Ana Gloria Gil; Eduardo Asin-Prieto; María José Saiz; Josep Manuel Llabrés. Pharmaceutics 2021, Volume 13, Issue 3, 361.
Oral administration of zein-based nanoparticles reduces glycemia and improves glucose tolerance in rats. Cristian Reboredo, Carlos J.González-Navarro, Ana L.Martínez-López, Juan M.Irache. International Journal of Pharmaceutics. Volume 628, 25 November 2022.
Encapsulation of Lactobacillus plantarum in casein-chitosan microparticles facilitates the arrival to the colon and develops an immunomodulatory effect. Rebeca Peñalva, Ana Luisa Martínez-López, Carlos Gamazo, Carlos J.Gonzalez-Navarro, Carolina González-Ferrero, Raquel Virto-Resano, Ana Brotons-Canto, Ana Isabel Vitas, Maria Collantes, Ivan Peñuelas, Juan M.Irache. Food Hydrocolloids. Volume 136, Part A, March 2023, 108213.
Encapsulated Phytomedicines against Cancer: Overcoming the “Valley of Death. Ana Brotons-Canto, Claudia P. Urueña, Izaskun Imbuluzqueta, Edurne Luque-Michel, Ana Luisa Martinez-López, Ricardo Ballesteros-Ramírez, Laura Rojas and Susana Fiorentino. Pharmaceutics 2023, 15(4), 1038; Special Issue «The Study of Plant Compounds in Antioxidant Activity and Anticancer Activity».
Doi: 10.3390/pharmaceutics15041038
3D printing of microencapsulated Lactobacillus rhamnosus for oral delivery. Pablo Rosas-Val, Masoud Adhami, Ana Brotons-Canto, Carlos Gamazo, Juan M. Irache, Eneko Larrañeta. International Journal of Pharmaceutics. Volume 641, 25 June 2023, 123058.
Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin. Raquel Campion, Carlos J. Gonzalez-Navarro, Ana Luisa Martínez Lopez, M. Cristina Martínez, María-Jose Saiz, Maria Collantes, Ivan Peñuelas, Juan M. Irache. International Journal of Pharmaceutics. Volume 643, 25 August 2023, 123216
Zein nanoparticles extend lifespan in C. elegans and SAMP8 mice. Ana L. Martínez-López, Cristian Reboredo, Carlos J. González-Navarro, Maite Solas, Elena Puerta, María Javier Ramírez, José L. Vizmanos, Juan M. Irache. International Journal of PharmaceuticsVolume 666, , 5 December 2024, 124798

Innovation

International patents

Active R+D projects

Countries worldwide

Toxicity Studies

Scientific publications

International
patents

Active R+D
projects

Countries
worldwide